Magnesium is a nutritional supplement with numerous effects that support cerebrovascular tone.

These include:

1) inhibition of platelet aggregation
2) interference with synthesis, release, and action of inflammatory mediators
3) direct alterations of cerebrovascular tone
4) inhibition of vasospasm
5) stabilization of cell membranes

Some migraine sufferers with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of Magnesium typically range from 200 to 600 mg to compensate for this deficiency — far above what’s found in most multi-vitamins.

-Migraine Headache Help

Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This led researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non-extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well.  Thus Puracol Feverfew, a non-extracted plant source with high levels of naturally occurring parthenolide was developed. Puracol Feverfew is superior in it’s effectiveness as it delivers optimal dosages of parthenolide.  Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.  It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena are associated with migraines.  European studies have shown the benefits of feverfew on long-term cerebrovasular tone.

-Migraine Headache Help